This system enables efficient, rapid, and specific binding to nucleic acids in solution under high-salt and low-pH conditions through hydrophobic interactions, hydrogen bonding, and electrostatic adsorption, without significant association with other impurities such as proteins. It allows rapid isolation of nucleic acids from biological samples, featuring straightforward and safe operation, and is suitable for automated and high-throughput nucleic acid extraction workflows, making it ideal for modern genomics and diagnostic applications